Well, I read the final TPB of Preacher yesterday and it is JUST. SO. AWESOME. There are only 75 issues in the entire series of Preacher: 66 regular single monthly issues, five one-shot specials and a four issue Saint of Killers mini-series. And the entire saga is just brilliant.
I can't just recommend it highly enough. I've recommended so much stuff to friends over the years...Watchmen is another one of my highly recommended titles, as well as Fables and most stuff written by Alan Moore. But for sheer great storytelling and comedy/dark humour, you just can't go beyond Preacher. Where else will you get to see a teenager with the face of an arse, a German ex-special ops soldier who's got a head that looks like a giant penis, just to name some of the more memorable characters?
I really like Garth Ennis' title to each single issue story too. He's got titles that are named after brilliant quotes from lyrics, such as "Freedom's just another word for nothing left to lose" ("Me and Bobby McGee" - Kris Kristofferson), and then he makes reference to the battle at the Alamo with Bowie, Crockett and Travis and the 180 men.
The Wikipedia entry on Preacher is pretty comprehensive too, for those who want to find out more about it. Not too many spoilers there either:
Preacher on Wikipedia
Started reading the latest TPB of Y - The Last Man yesterday...that's another super read, though nowhere close to as good as Preacher.